The LifeGenetics method

LifeGenetics is a new concept of how we live

The LifeGenetics method promotes expert and user friendly solutions for individual’s optimal nutrition and lifestyle. The aim is disease prevention, well-being and effective weight loss based on the information about individual’s genetic makeup thorugh innovative LifeGenetics DNA testing services that are based on the revolutionary nutrigenomic approach.

 

Expertise and quality

»Expertise at work and the quality of LifeGenetics services are our primary consideration«

LifeGenetics services are one of the most advanced and credible nutrigenomic analyses available to the general public. Namely, by examining up to 80 genetic variations, they are considered to be among the most extensive and comprehensive DNA analyses in the world. Few providers that deal with similar genetic tests on average cover only 5 to 24 genetic variations and do not include recommendations, made on the basis of the results. LifeGenetics genetic reports are based on laboratory results of genetic material produced in renowned laboratories and also consider information about individual’s personal characteristics and other given data. By doing that, we strive to present more holistic and in-depth final recommendations, which are tailored to individual’s genetic code.

In carrying out these analyses we work with renowned and accredited laboratories and implement procedures to achieve the highest level of quality. In comparison to related technologies that provide 61% success rate of gene analysis, technologies that are used for the preparation of LifeGenetics products provide 94% success rate of gene analysis.

All LifeGenetics services are developed by a team of highly qualified experts from the fields of genetics, biochemistry, medicine, pharmacy and nutrition, who, in order to provide best service, consider only the most reliable and statistically relevant researches, published in internationally recognized scientific publications.

 

Privacy and security

»We ensure discretion throughout the entire process«

Genelitik Ltd. respects your privacy and undertakes to protect your personal information, acquired via the web information system, and not to disclose any information to a third party or use it for other purposes without your consent.

The entire procedure of ordering LifeGenetics services is conducted discretely. After receiving consent form to perform genetic analysis and DNA sample, your personal and other information are separated from your DNA, since the sample is immediately encrypted and sent to a laboratory for analysis, where, after carrying out the analysis, is also immediately destroyed.

Your analysis, DNA results and relevant recommendations are presented in your personal, in the case of LifeGenetics Premium, an 80-page book that will be delivered to you personally in a discrete package via post.

 

Ethics

»We only provide information that enables you to take action«

We believe that the purpose of DNA testing is not only individual’s DNA analysis and/or diagnosis of genetic diseases; therefore instead of identifying poor genetic predispositions, we focus on providing interpretation and valuable information of those genetic variations, which allow you to use a given genetic code to your advantage and thus improve your well-being and lifestyle. An integral part of our services is an action plan that will enable you to achieve that goal. At the same time we strive to provide information in a manner that is comprehensible and user-friendly. We acknowledge the possibility of needing additional support and counseling when using LifeGenetics services; therefore we provide a team of professionals that will answer any additional questions and help you take the first steps towards a healthier and more quality lifestyle.

It is our duty and responsibility to continually research the area of genetics and nutrigenomics, and to perfect our products and services accordingly. That being said, professional experts systematically monitor and review latest scientific findings in the field of genetics and nutrigenomics.

 

How do we interpret your DNA?

LifeGenetics findings are based on the most reliable and cutting-edge research in the field of genetics, which has been published in prestigious international scientific journals. The laboratory genetic analyses also follow global trends since they are made using advanced modern technologies in reliable laboratories.

LifeGenetics Slim analyses are dedicated to those genetic variations for which reputable scientific studies have found a significant impact on the metabolic pathways of the body. When making interpretations, we take into account studies which were carried out using a large sample (thousands, possibly hundreds of thousands of people) and were therefore found to be statistically significant.

In order to provide a better understanding of the integration of science and genetics, we present some examples below:

 

1. Genetics makes a 40 to 70% contribution to the development of obesity

Irregularities in fat metabolism and their accumulation can lead to obesity, which can cause the onset of type two diabetes, high blood pressure, elevated blood lipid levels and cardiovascular diseases.

Obesity is defined by the body mass index (BMI; the weight in pounds (lbs) divided by height in inches (in) squared and multiplied by a conversion factor of 703) greater than or equal to 30. In Europe, this value is exceeded by 20% of the population, and in the U.S. by one-third, respectively. It is very disturbing that the percentage of children and adolescents who are defined as overweight has more than doubled in the last decade. Most people living in Western and Third World countries exceed the recommended daily intake of kilocalories (kcal) (2000 kcal for women, 2500 kcal for men and pregnant women, 4000 kcal for professional athletes). Therefore, the proportion of people who are either overweight or obese (BMI> 25) is increasing. The excess absorbed energy accumulates in the subcutaneous white fat tissue around internal organs, packed in between organs and inside the abdominal cavity. White fat serves as a reserve store of energy and is adapted to thermal insulation and mechanical protection. Fat is also an organ secreting important hormones called adipokines into the bloodstream. Because of these functional features we must strive towards optimum body fat percentage.

Genes that can influence obesity also regulate food intake (appetite), the basal metabolic rate (amount of energy required to maintain vital functions in an organism at complete rest), heat generation, fat cell differentiation, fat storage and carbohydrate and lipid metabolism. Studies including both identical and fraternal twins suggest that genetic factors explain 60-70 percent of the variance of these properties. Other types of research involving humans and animals have shown slightly lower values, although they still attribute a high percentage (40 to 50 percent) to genetic influence.

Obesity is a complex, multi-factorial disease that develops from the interaction between genes and lifestyle factors (eating patterns and a sedentary lifestyle). Currently it is estimated that genetic factors account for 40-70% of the variance in human adiposity.

Human obesity has a strong genetic component. About 20 different genes are linked to the monogenetic causes of obesity. The vast majority of cases have a polygenic background, where each gene is of little importance individually, yet they are important in the development of personalized treatment plans. This is also the reason why there is no universal way to treat people struggling with obesity, and thus why it is very important to understand both genetic background and lifestyle factors.

When making recommendations, LifeGenetics Slim takes into account both genetics and lifestyle factors and, among other things, analyzes one of the genes that affect a person’s likelihood of becoming obese.

 

2. Some people can eat fat and lose weight

Research shows that increases in body weight also depend on our genetic makeup.

As an example, consider the APOA5 gene, which has been shown to be involved in fat metabolism. More than 10% of the population carries the particular APOA5 gene variant that allows people to enjoy fatty foods without damaging their health. People who eat high fat foods are three times more likely to be obese, compared with those who do not have this version of the gene.

Fat metabolism is a very complex process, involving a lot of genetic variants. In the DNA test Slim we determine how an individual metabolizes some types of fatty acids, how fats are stored in the body, released, etc. A more appropriate weight-loss diet and adequate physical exercise can help reduce body fat percentage and contribute to better health.

DNA test Slim also analyzes the genes associated with fat metabolism.

3. Aerobic or anaerobic exercise? The answer lies in DNA!

General recommendations on how to lose weight in a healthy way suggest aerobic exercise in combination with a prudent diet, which accelerates fat burning and consequently facilitates weight-loss. However, such general recommendations do not take into account your genetic profile, which determines what kind of nutrients and exercise are the key to your weight-loss success.

Around 20% of the population does not get any significant aerobic fitness benefit from regular exercise, according to an international study led by scientists at the University of London. Millions of people who strive to keep fit and lose weight by jogging, swimming or going to the gym are wasting their time. Researchers have discovered that the health benefits of aerobic exercise are determined by our genes.

For these people, regular aerobic exercise will do little to ward off conditions like heart disease and diabetes which aerobic exercise is generally thought to resist.

More than 500 participants in Europe and the US were asked to undergo various aerobic training programs in line with government advice to do 30 minutes of exercise five times a week. By the end of the 20 week program, the majority of people had shown a measurable improvement in how much oxygen their body consumes during exercise, a key indicator of aerobic fitness.

But 20% saw their maximum oxygen increase by less than 5% – a negligible improvement. Approximately 30% showed no increase in insulin sensitivity, meaning that the exercise did not reduce their risk of diabetes.

A pioneering analysis of muscle tissue samples taken from the participants revealed a set of about 30 genes that predicted the increase in oxygen intake. Of these, 11 were shown to have a particular impact on the effectiveness of aerobic exercise.

Selecting an appropriate type of exercise is not only important for maximizing the efficiency of your athletic potential, but also for developing and maintaining vitality and a healthy lifestyle, and preventing certain diseases. The DNA test LifeGenetics Slim will answer your questions concerning the type of sports activity that best suits your genetic profile and will help you in choosing an effective and healthy weight-loss diet.

Additional information

The difference between aerobic and anaerobic exercises:

Aerobic exercise is carried out in the presence of abundant oxygen. This is physical exercise of moderate intensity. Aerobic exercise supplies enough oxygen to the muscles to burn fat. Examples of such exercise include light jogging, cycling, swimming, tennis, etc.

Anaerobic exercise is based on maximum effort and intensity, which cause a lack of oxygen in body tissues. Because of the lack of oxygen the organism cannot burn fats, so it burns carbohydrates instead.
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